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Circulating tumour cells escape from EpCAM-based detection due to epithelial-to-mesenchymal transition

BMC Cancer · 2012 · Vol. 12(1) · pp. 178–178

Tobias M. Gorges(Bayer (Germany))Ingeborg Tinhofer(Charité - Universitätsmedizin Berlin)Michael Drosch(Bayer (Germany))Lars Röse(Bayer (Germany))Thomas M. Zollner(Bayer (Germany))Thomas Krahn(Bayer (Germany))Oliver von Ahsen✉(Boehringer Ingelheim (Germany))

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Abstract

The use of EpCAM-based enrichment techniques leads to the failure to detect CTC populations that have undergone EMT. Our findings may explain clinical results where low CTC numbers have been reported even in patients with late metastatic cancers. These results are a starting point for the identification of new markers for detection or capture of CTCs, including the mesenchymal-like subpopulations.

Cancer Cells and Metastasis Cancer Genomics and Diagnostics Metastasis and carcinoma case studiesEpithelial–mesenchymal transitionCirculating tumor cellCancer researchProstate cancerMesenchymal stem cellMetastasisColorectal cancerBiologyCancerReal-time polymerase chain reaction

MeSH terms

Epithelial Cell Adhesion MoleculeAnimalsAntigens, NeoplasmBreast NeoplasmsCell SeparationFemaleHumansMice, NudeNeoplastic Cells, CirculatingNeoplasm MetastasisTransplantation, HeterologousBiomarkers, TumorCell Adhesion MoleculesCell Line, TumorMice