articleTop 1% cited
Clinical effects of Aβ immunization (AN1792) in patients with AD in an interrupted trial
Neurology · 2005 · Vol. 64(9) · pp. 1553–1562
S. Gilman✉(UK Dementia Research Institute)M. Köller(UK Dementia Research Institute)R. S. Black(UK Dementia Research Institute)Lisa Jenkins(UK Dementia Research Institute)Sue G. Griffith(UK Dementia Research Institute)Nick C. Fox(UK Dementia Research Institute)Larry S. Eisner(UK Dementia Research Institute)L. Kirby(UK Dementia Research Institute)Merçé Boada(UK Dementia Research Institute)F. Forette(UK Dementia Research Institute)Jean‐Marc Orgogozo(UK Dementia Research Institute)
Abstract
Although interrupted, this trial provides an indication that Abeta immunotherapy may be useful in Alzheimer disease.
Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration MechanismsMedicineInternal medicinePlaceboClinical Dementia RatingClinical trialTolerabilityDementiaGastroenterologyAdverse effectDisease
MeSH terms
AgedAged, 80 and overAlzheimer DiseaseAntibodiesBrainCognition DisordersDouble-Blind MethodDrug Administration ScheduleFemaleHumansInjections, IntramuscularMagnetic Resonance ImagingMaleMeningoencephalitisMiddle Aged
Funding
- Universität Zürich
Citations
1,308
FWCI
42.07
field-weighted impact
References
25
Percentile
100%
vs. same field & year
Citations per year
Cited by
Defeating Alzheimer's disease and other dementias: a priority for European science and society
The Lancet Neurology · 2016 · 1,667 citations
Therapeutics of Alzheimer's disease: Past, present and future
Neuropharmacology · 2013 · 744 citations
Aβ Oligomers – a decade of discovery
Journal of Neurochemistry · 2007 · 1,905 citations
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide
Nature Reviews Molecular Cell Biology · 2007 · 4,679 citations
The amyloid hypothesis for Alzheimer’s disease: a critical reappraisal
Journal of Neurochemistry · 2009 · 802 citations
Alzheimer's disease: clinical trials and drug development
The Lancet Neurology · 2010 · 1,199 citations
References
A new rating scale for Alzheimer's disease
American Journal of Psychiatry · 1984 · 4,157 citations
The Clinical Dementia Rating (CDR)
Neurology · 1993 · 9,838 citations
Subacute meningoencephalitis in a subset of patients with AD after Aβ42 immunization
Neurology · 2003 · 1,336 citations
Clinical diagnosis of Alzheimer's disease
Neurology · 1984 · 27,910 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.