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Exercise and Pharmacotherapy in the Treatment of Major Depressive Disorder

Psychosomatic Medicine · 2007 · Vol. 69(7) · pp. 587–596

James A. Blumenthal✉(Duke Medical Center)Michael A. BabyakP. Murali DoraiswamyLana L. WatkinsBenson M. HoffmanKrista A. BarbourSteve HermanW. Edward CraigheadAlisha L. BrosseRobert WaughAlan L. HinderliterAndrew Sherwood

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Abstract

The efficacy of exercise in patients seems generally comparable with patients receiving antidepressant medication and both tend to be better than the placebo in patients with MDD. Placebo response rates were high, suggesting that a considerable portion of the therapeutic response is determined by patient expectations, ongoing symptom monitoring, attention, and other nonspecific factors.

Physical Activity and Health Cardiovascular and exercise physiology Cardiac Health and Mental HealthSertralinePlaceboDepression (economics)Major depressive disorderMedicinePhysical therapyHamilton Rating Scale for DepressionAntidepressantRandomized controlled trialPill

MeSH terms

Antidepressive AgentsDepressive Disorder, MajorMajor Depressive DisorderDouble-Blind MethodExercise TherapyFemaleHumansMaleMiddle AgedProspective StudiesPsychotherapy, GroupTreatment OutcomeSertraline

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1,015

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21.05

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