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Neuropsychological testing of cognitive impairment in euthymic bipolar disorder: an individual patient data meta‐analysis

Acta Psychiatrica Scandinavica · 2013 · Vol. 128(3) · pp. 149–162

Corin Bourne✉(University of Oxford)Ömer Aydemır(Manisa Celal Bayar University)Vicent Balanzá‐Martínez(Centro de Investigación Biomédica en Red de Salud Mental)Emre Bora(University of Melbourne)Sofia BrissosJonathan Cavanagh(University of Glasgow)Luke Clark(University of Cambridge)Zeynep Çubukçuoğlu(LVR-Klinik Bonn)Vasco Videira Dias(Hospital de Santa Maria)Sandra Dittmann(Ludwig-Maximilians-Universität München)I. Nicol Ferrier(Newcastle University)David E. Fleck(University of Cincinnati Medical Center)Sophia Frangou(Icahn School of Medicine at Mount Sinai)Peter Gallagher(Newcastle University)Lisa Jones(University of Birmingham)Tuula Kieseppä(Peijas Hospital)Anabel Martínez‐Arán(Centro de Investigación Biomédica en Red de Salud Mental)Ingrid Melle(Oslo University Hospital)P. Brian Moore(Newcastle University)María Mur(Universitat de Lleida)Andrea Pfennig(University Hospital Carl Gustav Carus)Aurélie Raust(Hôpital Albert-Chenevier)Vesile Şentürk(Ankara University)Carmen Simonsen(Oslo University Hospital)Daniel J. Smıth(Cardiff University)Danielle Soares Bio(Universidade de São Paulo)Márcio Gerhardt Soeiro‐de‐Souza(Centro Universitário das Faculdades Metropolitanas Unidas)SAMUEL D. R. STODDART(University of Birmingham)Kjetil Sundet(Oslo University Hospital)Andreı̈ Szöke(Inserm)J. M. Thompson(Newcastle University)Carla Torrent(Universitat de Barcelona)Tiziana Zalla(Centre National de la Recherche Scientifique)Nick Craddock(Cardiff University)Ole A. Andreassen(University of Oslo)Marion Leboyer(Inserm)Eduard Vieta(Centro de Investigación Biomédica en Red de Salud Mental)Michael Bauer(University Hospital Carl Gustav Carus)Patrick D. Worhunsky(University of Oxford)Charidimos Tzagarakis(University of Oxford)Robert D. Rogers(University of Oxford)John Geddes(University of Oxford)Guy M. Goodwin(University of Oxford)

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Abstract

This reanalysis supports VLT, Digit Span and TMT as robust measures of cognitive impairments in bipolar disorder patients. The heterogeneity of some test results explains previous differences in meta-analyses. Better controlling for confounds suggests deficits may be smaller than previously reported but should be tracked longitudinally across illness progression and treatment.

Bipolar Disorder and Treatment Electroconvulsive Therapy Studies Adolescent and Pediatric HealthcareMemory spanPsychologyNeuropsychologyBipolar disorderMoodWisconsin Card Sorting TestCognitionTrail Making TestNeuropsychological testClinical psychology

MeSH terms

AdultAffectAffective SymptomsBipolar DisorderCognition DisordersFemaleHumansMaleMental ProcessesMiddle AgedNeuropsychological TestsPsychiatric Status Rating ScalesPsychotropic DrugsRisk FactorsConfounding Factors, Epidemiologic