article Open AccessTop 1% cited

Gut Microbiota-Dependent Trimethylamine <i>N</i> -Oxide (TMAO) Pathway Contributes to Both Development of Renal Insufficiency and Mortality Risk in Chronic Kidney Disease

Circulation Research · 2014 · Vol. 116(3) · pp. 448–455

W.H. Wilson Tang✉(Cleveland State University)Zeneng Wang(Cleveland State University)David J. Kennedy(Cleveland Clinic)Yuping Wu(Cleveland Clinic)Jennifer A. Buffa(Cleveland Clinic)Brendan Agatisa-Boyle(Cleveland Clinic)Xinmin S. Li(Cleveland State University)Bruce S. Levison(Cleveland State University)Stanley L. Hazen(Cleveland State University)

View via DOI Full-text PDF

Abstract

Plasma TMAO levels are both elevated in patients with CKD and portend poorer long-term survival. Chronic dietary exposures that increase TMAO directly contributes to progressive renal fibrosis and dysfunction in animal models.

Dialysis and Renal Disease Management Diet and metabolism studies Gut microbiota and healthTrimethylamine N-oxideKidney diseaseDiseaseChronic renal insufficiencyKidneyMedicineGut floraInternal medicineTrimethylamineEndocrinology

MeSH terms

AgedAged, 80 and overAnimalsFemaleHumansIntestinesMaleMethylaminesMice, Inbred C57BLMiddle AgedPrognosisRisk FactorsBiomarkersCase-Control StudiesMice

Citations

1,163

FWCI

33.80

field-weighted impact

References

Percentile

100%

vs. same field & year

Citations per year

Cited by

Implication of Trimethylamine N-Oxide (TMAO) in Disease: Potential Biomarker or New Therapeutic Target