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Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM

Nature Methods · 2013 · Vol. 10(6) · pp. 584–590
Xueming LiPaul MooneyShawn ZhengChristopher R. BoothMichael B. BraunfeldSander GubbensDavid A. AgardYifan Cheng
Advanced Electron Microscopy Techniques and ApplicationsPhotosynthetic Processes and MechanismsEnzyme Structure and FunctionCryo-electron microscopyResolution (logic)Single particle analysisElectronSymmetry (geometry)PhysicsParticle (ecology)OpticsChemistryMaterials science

MeSH terms

ElectronsMotionThermoplasmaCryoelectron MicroscopyImaging, Three-DimensionalProteasome Endopeptidase Complex

Funding

  • National Science Foundation
  • Howard Hughes Medical Institute
  • National Institutes of Health
  • University of California, San Francisco
  • Lawrence Berkeley National Laboratory
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