article Open AccessTop 10% cited
The discovery and development of HMG-CoA reductase inhibitors.
Journal of Lipid Research · 1992 · Vol. 33(11) · pp. 1569–1582
Akira Endo✉(Ryukoku University)
Abstract
During the 1950s and 1960s, many cholesterol-lowering agents were reported and introduced into clinical use, in-
Microbial Metabolism and ApplicationsPlant biochemistry and biosynthesisMicrobial Natural Products and BiosynthesisHMG-CoA reductaseReductaseHydroxymethylglutaryl-CoA Reductase InhibitorsDrug discoveryCholesterolPharmacologyChemistryComputational biologyMedicineBiochemistry
MeSH terms
AnimalsAnticholesteremic AgentsHumansHypercholesterolemiaLovastatinHydroxymethylglutaryl-CoA Reductase InhibitorsHistory, 20th Century
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References
Competitive inhibition of 3‐hydroxy‐3‐methylglutaryl coenzyme a reductase by ML‐236A and ML‐236B fungal metabolites, having hypocholesterolemic activity
FEBS Letters · 1976 · 799 citations
Influence of nicotinic acid on serum cholesterol in man
Archives of Biochemistry and Biophysics · 1955 · 722 citations
The Low-Density Lipoprotein Pathway and its Relation to Atherosclerosis
Annual Review of Biochemistry · 1977 · 2,465 citations
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