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The long non-coding RNA HOTAIR indicates a poor prognosis and promotes metastasis in non-small cell lung cancer

BMC Cancer · 2013 · Vol. 13(1) · pp. 464–464

Xiang-hua Liu✉(Nanjing Medical University)Zhili Liu(Second Affiliated Hospital of Nanjing Medical University)Ming Sun(Nanjing Medical University)Jing Liu(Second Affiliated Hospital of Nanjing Medical University)Zhao-xia Wang(Second Affiliated Hospital of Nanjing Medical University)Wei De(Nanjing Medical University)

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Abstract

Our findings indicate that HOTAIR is significantly up-regulated in NSCLC tissues, and regulates NSCLC cell invasion and metastasis, partially via the down-regulation of HOXA5. Thus, HOTAIR may represent a new marker of poor prognosis and is a potential therapeutic target for NSCLC intervention.

Cancer-related molecular mechanisms research RNA Research and SplicingHOTAIRCancer researchLong non-coding RNABiologyGene knockdownMetastasisLung cancerRNA interferenceCancerCell culture

MeSH terms

Carcinoma, Non-Small-Cell LungCell MovementFemaleHumansLung NeoplasmsMaleNeoplasm MetastasisNeoplasm StagingPrognosisGene Expression Regulation, NeoplasticApoptosisHomeodomain ProteinsMatrix Metalloproteinase 2Matrix Metalloproteinase 9Cell Line, Tumor