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Effect of annual intramuscular vitamin D on fracture risk in elderly men and women a population-based, randomized, double-blind, placebo-controlled trial

Lara D. Veeken · 2007 · Vol. 46(12) · pp. 1852–1857

Helen Smith✉F Anderson(British Geriatrics Society)H Raphael(Southampton General Hospital)P. Maslin(Southampton General Hospital)Sarah Crozier(University of Southampton)Cyrus Cooper(Southampton General Hospital)

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Abstract

An annual i.m. injection of 300,000 IU vitamin D2 is not effective in preventing non-vertebral fractures among elderly men and women resident in the general population.

Vitamin D Research Studies Vitamin C and Antioxidants Research Bone health and osteoporosis researchMedicinePlaceboRandomized controlled trialDouble blindPopulationPhysical therapyVitamin D and neurologyInternal medicineAlternative medicineEnvironmental health

MeSH terms

AgedAged, 80 and overDose-Response Relationship, DrugDouble-Blind MethodDrug Administration ScheduleErgocalciferolsFemaleFollow-Up StudiesFractures, SpontaneousHumansInjections, IntramuscularMaleOsteoporosisProbabilityReference Values