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High Plasma Concentration of Factor VIIIc Is a Major Risk Factor for Venous Thromboembolism

Thrombosis and Haemostasis · 2000 · Vol. 83(01) · pp. 5–9

Pieternella in 't Anker✉Marianne KoopmanP.H. ReitsmaMartin H. PrinsAbraham van den EndeHarry BüllerRoderik A. Kraaijenhagen(Academic Medical Center)

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Abstract

Elevated plasma levels of factor VIIIc are a significant, prevalent, independent and dose-dependent risk factor for venous thromboembolism. It also predisposes to recurrent venous thromboembolism.

Blood Coagulation and Thrombosis Mechanisms Venous Thromboembolism Diagnosis and Management Atrial Fibrillation Management and OutcomesMedicineRisk factorFactor V LeidenInternal medicineVenous thromboembolismFibrinogenGastroenterologyFactor VPathogenesisThrombophilia

MeSH terms

AdultAgedFactor VIIIFemaleHumansMaleMiddle AgedPedigreeRisk FactorsVenous Thrombosis

Citations

485

FWCI

13.90

field-weighted impact

References

Percentile

99%

vs. same field & year

Citations per year

References

A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis

Blood · 1996 · 3,106 citations

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