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Perioperative Chemotherapy Compared With Surgery Alone for Resectable Gastroesophageal Adenocarcinoma: An FNCLCC and FFCD Multicenter Phase III Trial
Journal of Clinical Oncology · 2011 · Vol. 29(13) · pp. 1715–1721
Marc Ychou✉(CHU Dijon Bourgogne)Valérie Boige(CHU Dijon Bourgogne)Jean‐Pierre Pignon(CHU Dijon Bourgogne)Thierry Conroy(CHU Dijon Bourgogne)Olivier Bouché(CHU Dijon Bourgogne)G. Lebreton(CHU Dijon Bourgogne)Muriel Ducourtieux(CHU Dijon Bourgogne)Laurent Bedenne(CHU Dijon Bourgogne)Jean-Michel Fabre(CHU Dijon Bourgogne)B. Saint‐Aubert(CHU Dijon Bourgogne)Jean Genève(CHU Dijon Bourgogne)P Lasser(CHU Dijon Bourgogne)P. Rougier(CHU Dijon Bourgogne)
Abstract
In patients with resectable adenocarcinoma of the lower esophagus, GEJ, or stomach, perioperative chemotherapy using fluorouracil plus cisplatin significantly increased the curative resection rate, disease-free survival, and OS.
Esophageal Cancer Research and TreatmentGastric Cancer Management and OutcomesGastrointestinal Tumor Research and TreatmentMedicinePerioperativeAdenocarcinomaSurgeryRegimenChemotherapyHazard ratioCisplatinGastroenterologyClinical endpoint
MeSH terms
AdultAgedAntineoplastic Combined Chemotherapy ProtocolsCisplatinCombined Modality TherapyDrug Administration ScheduleEsophageal NeoplasmsEsophagogastric JunctionFemaleFluorouracilHumansMaleMiddle AgedStomach NeoplasmsChemotherapy, Adjuvant
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References
Changing patterns in the incidence of esophageal and gastric carcinoma in the United States
Cancer · 1998 · 2,092 citations
Perioperative Chemotherapy versus Surgery Alone for Resectable Gastroesophageal Cancer
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