review Open AccessTop 1% cited
Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy
Cancer Cell · 2015 · Vol. 27(4) · pp. 450–461
Suzanne L. Topalian✉(Sidney Kimmel Comprehensive Cancer Center)Charles G. Drake(Johns Hopkins University)Drew M. Pardoll(Sidney Kimmel Comprehensive Cancer Center)
Cancer Immunotherapy and BiomarkersImmune Cell Function and InteractionNeuroendocrine Tumor Research AdvancesBlockadeImmune checkpointCancer therapyImmune systemCancerCancer researchImmunologyMedicineComputational biologyBiology
MeSH terms
Antibodies, MonoclonalAntineoplastic AgentsHumansImmunotherapyNeoplasmsCD28 AntigensModels, ImmunologicalCTLA-4 AntigenProgrammed Cell Death 1 Receptor
Funding
- Pfizer
Citations
4,168
FWCI
160.79
field-weighted impact
References
121
Percentile
100%
vs. same field & year
Citations per year
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References
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The Lancet Oncology · 2014 · 1,480 citations
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Journal of Clinical Oncology · 2010 · 2,913 citations
Tumor antigen–specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired
Blood · 2009 · 1,751 citations
Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
Nature Medicine · 2002 · 4,970 citations
Programmed Death-1 Ligand 1 Interacts Specifically with the B7-1 Costimulatory Molecule to Inhibit T Cell Responses
Immunity · 2007 · 1,731 citations
CD28 and CTLA‐4 coreceptor expression and signal transduction
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