article Open AccessTop 10% cited
Effects of sex steroids on components of the insulin resistance syndrome in transsexual subjects
Clinical Endocrinology · 2003 · Vol. 58(5) · pp. 562–571
Jolanda M. H. Elbers(Wageningen University & Research)Erik J. Giltay✉(Wageningen University & Research)Tom Teerlink(University Clinical Centre)P Scheffer(University Clinical Centre)Henk AsschemanJacob C. SeidellLouis Gooren
Abstract
The effects of cross-sex hormone treatment - in the dosages used in this study - in healthy, nonobese, young transsexual subjects do not show unequivocally that female sex steroids, given in large amounts to male subjects, have beneficial effects on cardiovascular profile and that high dose testosterone administration to female subjects is detrimental with respect to cardiovascular risk.
Hormonal and reproductive studiesPharmacology and Obesity TreatmentOvarian function and disordersEndocrinologyInternal medicineInsulin resistanceMedicineCyproterone acetateSex hormone-binding globulinTestosterone (patch)CyproteroneBody mass indexInsulin
MeSH terms
Adipose TissueAdolescentAdultBlood PressureBody WeightEstradiolEthinyl EstradiolFemaleHumansInsulinLipoprotein LipaseLipoproteinsMaleProspective StudiesTestosterone
Funding
- Vrije Universiteit Amsterdam
Citations
314
FWCI
3.94
field-weighted impact
References
67
Percentile
94%
vs. same field & year
Citations per year
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References
Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal Women: Principal Results From the Women's Health Initiative Randomized Controlled Trial
JAMA · 2002 · 15,739 citations
Insulin Resistance: A Multifaceted Syndrome Responsible for NIDDM, Obesity, Hypertension, Dyslipidemia, and Atherosclerotic Cardiovascular Disease
Diabetes Care · 1991 · 4,536 citations
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