articleTop 1% cited
Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: Consequences for pravastatin pharmacokinetics
Clinical Pharmacology & Therapeutics · 2003 · Vol. 73(6) · pp. 554–565
Yohei Nishizato✉(Tottori University Hospital)
Abstract
Certain commonly occurring single-nucleotide polymorphisms in OATP-C, such as T521C (Val174Ala), are likely to be associated with altered pharmacokinetics of pravastatin. Large clinical studies are needed to confirm these observations.
Drug Transport and Resistance MechanismsPharmacological Effects and Toxicity StudiesPharmacogenetics and Drug MetabolismOrganic anion-transporting polypeptideNonsynonymous substitutionOrganic anion transporter 1PravastatinPharmacokineticsSingle-nucleotide polymorphismGeneBiologyPharmacologyTransporter
MeSH terms
AdultAllelesBiotransformationDNAGene FrequencyHaplotypesHumansJapanTerminology as TopicPolymorphism, GeneticPravastatinHydroxymethylglutaryl-CoA Reductase InhibitorsArea Under CurveReverse Transcriptase Polymerase Chain ReactionLiver-Specific Organic Anion Transporter 1
Citations
511
FWCI
18.44
field-weighted impact
References
33
Percentile
100%
vs. same field & year
Citations per year
Cited by
Drug interactions with lipid-lowering drugs: Mechanisms and clinical relevance
Clinical Pharmacology & Therapeutics · 2006 · 842 citations
Importance of P-glycoprotein at blood–tissue barriers
Trends in Pharmacological Sciences · 2004 · 582 citations
OATPs, OATs and OCTs: the organic anion and cation transporters of the<i>SLCO</i>and<i>SLC22A</i>gene superfamilies
British Journal of Pharmacology · 2011 · 744 citations
Different Effects of SLCO1B1 Polymorphism on the Pharmacokinetics of Atorvastatin and Rosuvastatin
Clinical Pharmacology & Therapeutics · 2007 · 429 citations
Membrane transporters in drug development
Nature Reviews Drug Discovery · 2010 · 3,297 citations
Rosuvastatin pharmacokinetics and pharmacogenetics in white and Asian subjects residing in the same environment
Clinical Pharmacology & Therapeutics · 2005 · 476 citations
Transporters and drug therapy: Implications for drug disposition and disease
Clinical Pharmacology & Therapeutics · 2005 · 496 citations
Impact of OATP transporters on pharmacokinetics
British Journal of Pharmacology · 2009 · 976 citations
References
A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane
American Journal of Physiology-Gastrointestinal and Liver Physiology · 2000 · 617 citations
Identification and Characterization of Human Organic Anion Transporter 3 Expressing Predominantly in the Kidney
Molecular Pharmacology · 2001 · 504 citations
Expression of P-glycoprotein in Human Placenta: Relation to Genetic Polymorphism of the Multidrug Resistance (MDR)-1 Gene
Journal of Pharmacology and Experimental Therapeutics · 2001 · 535 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.