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Neural stem cell proliferation is decreased in schizophrenia, but not in depression

Molecular Psychiatry · 2006 · Vol. 11(5) · pp. 514–522

Andreas Reif✉(University of Würzburg)Sabrina Fritzen(University of Würzburg)Michael S. Finger(University of Würzburg)Alexander Strobel(TU Dresden)Martin Lauer(University of Würzburg)Angelika Schmitt(University of Würzburg)Klaus‐Peter Lesch(University of Würzburg)

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Neurogenesis and neuroplasticity mechanisms Axon Guidance and Neuronal Signaling Epigenetics and DNA MethylationNeurogenesisDentate gyrusNeural stem cellSchizophrenia (object-oriented programming)NeuroscienceHippocampusAntidepressantPsychologyNeuropathologyDepression (economics)

MeSH terms

AnimalsBipolar DisorderCell CountDepressive Disorder, MajorMajor Depressive DisorderFemaleHippocampusHumansMaleMice, Inbred C57BLNeuronsPostmortem ChangesSchizophreniaStem CellsTissue Distribution

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The mood-improving actions of antidepressants do not depend on neurogenesis but are associated with neuronal remodeling