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The alternative product from the human CDKN2A locus, p14ARF, participates in a regulatory feedback loop with p53 and MDM2

The EMBO Journal · 1998 · Vol. 17(17) · pp. 5001–5014
Francesca J. Stott
Cancer-related Molecular PathwaysEpigenetics and DNA MethylationDNA Repair MechanismsBiologyp14arfCDKN2AGeneticsLocus (genetics)Mdm2Feedback loopComputational biologyGeneTumor suppressor gene

MeSH terms

Amino Acid SequenceCell CycleFeedbackHumansModels, GeneticMolecular Sequence DataNuclear ProteinsProtein BindingProteinsProto-Oncogene ProteinsGene Expression Regulation, NeoplasticTumor Suppressor Protein p53Sequence Homology, Amino AcidAlternative SplicingCyclin-Dependent Kinase Inhibitor p16
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References
mdm2 expression is induced by wild type p53 activity.
The EMBO Journal · 1993 · 1,285 citations
Inhibition of cyclin-dependent kinases by p21.
Molecular Biology of the Cell · 1995 · 1,018 citations
Inhibitors of mammalian G1 cyclin-dependent kinases.
Genes & Development · 1995 · 3,256 citations
A role for both RB and p53 in the regulation of human cellular senescence*1
Experimental Cell Research · 1991 · 746 citations
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