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Distinct Risk Factor Profiles for Human Papillomavirus Type 16–Positive and Human Papillomavirus Type 16–Negative Head and Neck Cancers

JNCI Journal of the National Cancer Institute · 2008 · Vol. 100(6) · pp. 407–420
Maura L. GillisonGypsyamber DʼSouzaWilliam H. WestraElizabeth A. SugarWeihong XiaoShahnaz BegumRaphael P. Viscidi

Abstract

HPV-16-positive HNSCCs and HPV-16-negative HNSCCs have different risk factor profiles, indicating that they should be considered to be distinct cancers.

Head and Neck Cancer StudiesCervical Cancer and HPV ResearchCleft Lip and Palate ResearchMedicineOncologyInternal medicineOdds ratioRisk factorHead and neck squamous-cell carcinomaLogistic regressionHuman papillomavirusCase-control studyCancer

MeSH terms

AdultAgedAlcohol DrinkingAntibodies, ViralCarcinoma, Squamous CellDNA, ViralFemaleHead and Neck NeoplasmsHumansMaleMarijuana SmokingMiddle AgedOral HygieneRisk FactorsSexual Behavior

Funding

  • Damon Runyon Cancer Research Foundation
  • National Institute of Dental and Craniofacial Research
Citations
1,535
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58.69
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57
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Journal of Leukocyte Biology · 2003 · 519 citations
Evidence for a Causal Association Between Human Papillomavirus and a Subset of Head and Neck Cancers
JNCI Journal of the National Cancer Institute · 2000 · 3,090 citations
Human Papillomavirus and Oral Cancer: The International Agency for Research on Cancer Multicenter Study
JNCI Journal of the National Cancer Institute · 2003 · 1,219 citations
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