article Open AccessTop 1% cited
Obesity and Systemic Oxidative Stress
Arteriosclerosis Thrombosis and Vascular Biology · 2003 · Vol. 23(3) · pp. 434–439
John F. Keaney✉(Boston University)Martin G. Larson(Boston University)Ramachandran S. Vasan(Boston University)Peter W.F. Wilson(Boston University)Izabella Lipinska(Boston University)Diane Corey(Boston University)Joseph M. Massaro(Boston University)Patrice Sutherland(Boston University)Joseph A. Vita(Boston University)Emelia J. Benjamin(Boston University)
Abstract
Smoking, diabetes, and body mass index were highly associated with systemic oxidative stress as determined by creatinine-indexed urinary 8-epi-PGF2alpha levels. The effect of body mass index was minimally affected by blood glucose, and diabetes and may suggest an important role of oxidative stress in the deleterious impact of obesity on cardiovascular disease.
Vitamin C and Antioxidants ResearchAntioxidant Activity and Oxidative StressSodium Intake and HealthBody mass indexMedicineCreatinineInternal medicineDiabetes mellitusEndocrinologyFramingham Heart StudyOxidative stressPopulationCohort
MeSH terms
AdultAgedAged, 80 and overDiabetes MellitusFemaleHumansMaleMiddle AgedObesityRisk FactorsSex FactorsSmokingDinoprostComorbidityBody Mass Index
Funding
- American Heart Association
- National Institutes of Health
- National Heart, Lung, and Blood Institute
Citations
1,296
FWCI
37.96
field-weighted impact
References
39
Percentile
100%
vs. same field & year
Citations per year
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References
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Journal of Clinical Investigation · 1993 · 1,774 citations
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American Journal of Epidemiology · 1979 · 1,661 citations
Role of oxidized low density lipoprotein in atherogenesis.
Journal of Clinical Investigation · 1991 · 2,670 citations
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