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Cancer risk in 680 000 people exposed to computed tomography scans in childhood or adolescence: data linkage study of 11 million Australians
BMJ · 2013 · Vol. 346(may21 1) · pp. f2360–f2360
John D. Mathews✉(University of Melbourne)Anna Forsythe(University of Melbourne)Zoe Brady(Alfred Health)Marcus W. Butler(Department of Health)Stacy Goergen(Monash University)Graham Byrnes(Centre International de Recherche sur le Cancer)Graham G. Giles(Cancer Council Victoria)A. B. Wallace(Australian Radiation Protection and Nuclear Safety Agency)P. R. Anderson(University of Canberra)Tenniel Guiver(Australian Institute of Health and Welfare)Paul McGale(University of Oxford)Tim Cain(Royal Children's Hospital)James G. Dowty(University of Melbourne)Adrian Bickerstaffe(University of Melbourne)Sarah C. Darby(University of Oxford)
Abstract
The increased incidence of cancer after CT scan exposure in this cohort was mostly due to irradiation. Because the cancer excess was still continuing at the end of follow-up, the eventual lifetime risk from CT scans cannot yet be determined. Radiation doses from contemporary CT scans are likely to be lower than those in 1985-2005, but some increase in cancer risk is still likely from current scans. Future CT scans should be limited to situations where there is a definite clinical indication, with every scan optimised to provide a diagnostic CT image at the lowest possible radiation dose.
Radiation Dose and ImagingGlobal Cancer Incidence and ScreeningRadioactivity and Radon MeasurementsMedicineRecord linkageCohortIncidence (geometry)CancerConfidence intervalCohort studyCancer registryRate ratioDemography
MeSH terms
AdolescentAustraliaChildChild, PreschoolEpidemiologic MethodsFemaleHumansInfantMaleNeoplasms, Radiation-InducedRadiation DosageSocioeconomic FactorsTime FactorsTomography, X-Ray ComputedAge Distribution
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1,979
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field-weighted impact
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56
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100%
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References
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Projected Cancer Risks From Computed Tomographic Scans Performed in the United States in 2007
Archives of Internal Medicine · 2009 · 1,865 citations
Computed Tomography — An Increasing Source of Radiation Exposure
New England Journal of Medicine · 2007 · 8,611 citations
International Commission on Radiological Protection
Radiology · 1969 · 2,158 citations
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