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Cancer risks in <i>BRCA2</i> families: estimates for sites other than breast and ovary

Journal of Medical Genetics · 2005 · Vol. 42(9) · pp. 711–719

Christi J. van Asperen(Leiden University Medical Center)R M Brohet(The Netherlands Cancer Institute)E J Meijers-Heijboer(Erasmus MC)N Hoogerbrugge(Radboud University Nijmegen)S Verhoef(Cancer Clinic)H F A Vasen(Netherlands Consortium for Healthy Ageing)M G E M Ausems(University Medical Center Utrecht)F H Menko(University Hospital and Clinics)E B Gomez Garcia(University Medical Center)J G M Klijn(Erasmus University Rotterdam)F B L Hogervorst(Cancer Clinic)J C van Houwelingen(Leiden University Medical Center)L J van’t Veer(The Netherlands Cancer Institute)M A Rookus(Oncode Institute)F E van Leeuwen✉(The Netherlands Cancer Institute)

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Abstract

We found that BRCA2 carriers are at increased risk for cancers of the prostate and pancreas, and possibly bone and pharynx. Larger databases with extended follow up are needed to provide insight into mutation specific risks of selected carriers in BRCA2 families.

BRCA gene mutations in cancer Nutrition, Genetics, and Disease Ovarian cancer diagnosis and treatmentOvarian cancerBreast cancerCancerRelative riskFamily historyGynecologyIncidence (geometry)Internal medicineMedicineOncology

MeSH terms

AdultAgedBone NeoplasmsBreast NeoplasmsFemaleHumansMaleMiddle AgedNetherlandsOvarian NeoplasmsPancreatic NeoplasmsPharyngeal NeoplasmsProstatic NeoplasmsRiskCohort Studies

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ACG Clinical Guideline: Genetic Testing and Management of Hereditary Gastrointestinal Cancer Syndromes