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Bayesian Phylogenetics with BEAUti and the BEAST 1.7

Molecular Biology and Evolution · 2012 · Vol. 29(8) · pp. 1969–1973
Alexei J. DrummondMarc A. SuchardDong XieAndrew Rambaut

Abstract

Computational evolutionary biology, statistical phylogenetics and coalescent-based population genetics are becoming increasingly central to the analysis and understanding of molecular sequence data. We present the Bayesian Evolutionary Analysis by Sampling Trees (BEAST) software package version 1.7, which implements a family of Markov chain Monte Carlo (MCMC) algorithms for Bayesian phylogenetic inference, divergence time dating, coalescent analysis, phylogeography and related molecular evolutionary analyses. This package includes an enhanced graphical user interface program called Bayesian Evolutionary Analysis Utility (BEAUti) that enables access to advanced models for molecular sequence and phenotypic trait evolution that were previously available to developers only. The package also provides new tools for visualizing and summarizing multispecies coalescent and phylogeographic analyses. BEAUti and BEAST 1.7 are open source under the GNU lesser general public license and available at http://beast-mcmc.googlecode.com and http://beast.bio.ed.ac.uk.

Genetic diversity and population structureGenomics and Phylogenetic StudiesEvolution and Paleontology StudiesCoalescent theoryMarkov chain Monte CarloBiologyEvolutionary biologyPhylogenetic treeBayesian probabilityPhylogeneticsPhylogeographyMost recent common ancestorComputer science

MeSH terms

AnimalsBase SequenceBayes TheoremDNA, MitochondrialMolecular Sequence DataPhenotypePhylogenySoftwareUser-Computer InterfaceComputational BiologyFinches

Funding

  • National Science Foundation
  • National Evolutionary Synthesis Center
  • Wellcome Trust
  • Royal Society
  • Directorate for Biological Sciences
  • Biotechnology and Biological Sciences Research Council
Citations
10,346
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References
Sampling-through-time in birth–death trees
Journal of Theoretical Biology · 2010 · 571 citations
Bayesian Phylogeography Finds Its Roots
PLoS Computational Biology · 2009 · 1,888 citations
Bayesian Inference of Species Trees from Multilocus Data
Molecular Biology and Evolution · 2009 · 2,556 citations
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