articleTop 1% cited
A Randomized Controlled Trial of Fluorouracil Plus Leucovorin, Irinotecan, and Oxaliplatin Combinations in Patients With Previously Untreated Metastatic Colorectal Cancer
Journal of Clinical Oncology · 2003 · Vol. 22(1) · pp. 23–30
Richard M. Goldberg✉(North Central Cancer Treatment Group)Daniel J. Sargent(North Central Cancer Treatment Group)Roscoe F. Morton(North Central Cancer Treatment Group)Charles S. Fuchs(North Central Cancer Treatment Group)Ramesh K. Ramanathan(North Central Cancer Treatment Group)Stephen K. Williamson(North Central Cancer Treatment Group)B. Findlay(North Central Cancer Treatment Group)Henry C. Pitot(North Central Cancer Treatment Group)Steven R. Alberts(North Central Cancer Treatment Group)
Abstract
The FOLFOX regimen of oxaliplatin and infused fluorouracil plus leucovorin was active and comparatively safe. It should be considered as a standard therapy for patients with advanced colorectal cancer.
Colorectal Cancer Treatments and StudiesCancer Treatment and PharmacologyGastric Cancer Management and OutcomesMedicineIrinotecanOxaliplatinFluorouracilColorectal cancerInternal medicineOncologyRandomized controlled trialChemotherapyCancer
MeSH terms
AdenocarcinomaAdultAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsCamptothecinLeucovorinFemaleFluorouracilHumansInfusions, IntravenousInjections, IntravenousMaleMiddle AgedOrganoplatinum Compounds
Funding
- Pfizer
- National Cancer Institute
Citations
2,265
FWCI
66.44
field-weighted impact
References
23
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100%
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References
Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.
Journal of Biological Chemistry · 1985 · 2,338 citations
Oxaliplatin, tetraplatin, cisplatin, and carboplatin: Spectrum of activity in drug-resistant cell lines and in the cell lines of the national cancer institute's anticancer drug screen panel
Biochemical Pharmacology · 1996 · 614 citations
Cancer Statistics, 2002
CA A Cancer Journal for Clinicians · 2002 · 2,929 citations
A Multiple Testing Procedure for Clinical Trials
Biometrics · 1979 · 3,326 citations
Leucovorin and Fluorouracil With or Without Oxaliplatin as First-Line Treatment in Advanced Colorectal Cancer
Journal of Clinical Oncology · 2000 · 3,810 citations
Bevacizumab plus Irinotecan, Fluorouracil, and Leucovorin for Metastatic Colorectal Cancer
New England Journal of Medicine · 2004 · 10,930 citations
Regression Models and Life-Tables
Journal of the Royal Statistical Society Series B (Statistical Methodology) · 1972 · 38,926 citations
Nonparametric Estimation from Incomplete Observations
Journal of the American Statistical Association · 1958 · 38,793 citations
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