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Women with polycystic ovary syndrome have intrinsic insulin resistance on euglycaemic-hyperinsulaemic clamp

Human Reproduction · 2013 · Vol. 28(3) · pp. 777–784

Nigel K. Stepto(Monash University)Samantha Cassar(Victoria University)Anju E. Joham(Monash University)Stephen Hutchison(Monash University)Cheryce L. Harrison(Monash University)Rebecca F. Goldstein(Monash University)Helena Teede✉(Monash University)

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Abstract

This investigator-initiated trial was supported by grants from the National Health & Medical Research Council (NHMRC) Grant number 606553 (H.J.T., N.K.S. and S.K.H.) as well as Monash University and The Jean Hailes Foundation. H.J.T. is an NHMRC Research Fellow. N.K.S. is supported through the Australian Government's Collaborative Research Networks (CRN) programme. A.E.J. is a Jean Hailes and NHMRC scholarship holder. The authors declare that there is no conflict of interest associated with this manuscript.

Ovarian function and disorders Reproductive Biology and Fertility Lipid metabolism and disordersPolycystic ovaryInsulin resistanceMedicineEndocrinologyInternal medicineClampOvaryInsulinGynecology

MeSH terms

Academic Medical CentersAdultCross-Sectional StudiesFemaleFollicular PhaseHumansInsulin ResistanceObesityOutpatient Clinics, HospitalPolycystic Ovary SyndromePrediabetic StateVictoriaGlucose Clamp TechniqueCohort StudiesBody Mass Index