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Counting the Uncountable: Statistical Approaches to Estimating Microbial Diversity

Applied and Environmental Microbiology · 2001 · Vol. 67(10) · pp. 4399–4406
J.B. HughesJessica J. HellmannTaylor H. RickettsBrendan J. M. Bohannan

Abstract

All biologists who sample natural communities are plagued with the problem of how well a sample reflects a community's “true” diversity. New genetic techniques have revealed extensive microbial diversity that was previously undetected with culture-dependent methods and morphological

Gut microbiota and healthGenetic diversity and population structureEvolution and Genetic DynamicsDiversity (politics)Genetic diversitySample (material)BiologyUncountable setEvolutionary biologyMathematicsSociologyAnthropologyPopulation

MeSH terms

BacteriaEnvironmental MicrobiologyHumansMouthStatistics as TopicStomachColony Count, MicrobialEcosystemBacterial Physiological Phenomena

Funding

  • National Science Foundation
  • Fundación Costa Rica Estados Unidos para la Cooperación
Citations
1,302
FWCI
11.57
field-weighted impact
References
71
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99%
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References
The Commonness, And Rarity, of Species
Ecology · 1948 · 1,993 citations
Estimating terrestrial biodiversity through extrapolation
Philosophical Transactions of the Royal Society B Biological Sciences · 1994 · 4,553 citations
Bias caused by template annealing in the amplification of mixtures of 16S rRNA genes by PCR
Applied and Environmental Microbiology · 1996 · 1,890 citations
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