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Relationship between T Cell Activation and CD4 + T Cell Count in HIV‐Seropositive Individuals with Undetectable Plasma HIV RNA Levels in the Absence of Therapy

The Journal of Infectious Diseases · 2007 · Vol. 197(1) · pp. 126–133

Peter W. Hunt✉(University of California, San Francisco)Jason M. Brenchley(National Institutes of Health)Elizabeth Sinclair(University of California, San Francisco)Joseph M. McCune(University of California, San Francisco)Michelle E. Roland(University of California, San Francisco)Kimberly Page(San Francisco AIDS Foundation)Priscilla Y. Hsue(San Francisco General Hospital)Brinda Emu(University of California, San Francisco)Melissa Krone(University of California, San Francisco)Harry Lampiris(University of California, San Francisco)Daniel C. Douek(National Institutes of Health)Jeffrey N. Martin(San Francisco AIDS Foundation)Steven G. Deeks(University of California, San Francisco)

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Abstract

HIV controllers have abnormally high T cell activation levels, which may contribute to progressive CD4(+) T cell loss even without measurable viremia.

HIV Research and Treatment Immune Cell Function and Interaction HIV/AIDS Research and InterventionsVirologyLentivirusHuman immunodeficiency virus (HIV)RNAImmunologyImmunopathologyViral diseaseMedicineBiologyGenetics

MeSH terms

AdultFemaleHIV SeropositivityHumansLymphocyte ActivationMaleMiddle AgedRNA, ViralT-LymphocytesViremiaCohort StudiesHIV-1HIV InfectionsCD4 Lymphocyte Count

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636

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11.06

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Post-Treatment HIV-1 Controllers with a Long-Term Virological Remission after the Interruption of Early Initiated Antiretroviral Therapy ANRS VISCONTI Study