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Meta-Analysis of Concomitant Versus Sequential Radiochemotherapy in Locally Advanced Non–Small-Cell Lung Cancer
Journal of Clinical Oncology · 2010 · Vol. 28(13) · pp. 2181–2190
Anne Aupérin✉(Université de Montpellier)C. Le Péchoux(Université de Montpellier)Estelle Rolland(Université de Montpellier)Walter J. Curran(Université de Montpellier)Kiyoyuki Furuse(Université de Montpellier)P. Fournel(Université de Montpellier)J. Belderbos(Université de Montpellier)Gerald H. Clamon(Université de Montpellier)H Cüneyt Ulutin(Université de Montpellier)Rebecca Paulus(Université de Montpellier)Takeharu Yamanaka(Université de Montpellier)Marie‐Cécile Bozonnat(Université de Montpellier)A. L. J. Uitterhoeve(Université de Montpellier)Xiaofei Wang(Université de Montpellier)Lesley Stewart(Université de Montpellier)R. Arriagada(Université de Montpellier)Sarah Burdett(Université de Montpellier)Jean‐Pierre Pignon(Université de Montpellier)
Abstract
Concomitant radiochemotherapy, as compared with sequential radiochemotherapy, improved survival of patients with locally advanced NSCLC, primarily because of a better locoregional control, but at the cost of manageable increased acute esophageal toxicity.
Lung Cancer Diagnosis and TreatmentAdvanced Radiotherapy TechniquesHead and Neck Cancer StudiesConcomitantMedicineInternal medicineHazard ratioLung cancerOncologyRandomized controlled trialChemotherapyRadiation therapyProgression-free survival
MeSH terms
AdultAgedAged, 80 and overAntineoplastic AgentsCarcinoma, Non-Small-Cell LungDrug Administration ScheduleEsophagusFemaleHumansLung NeoplasmsMaleMiddle AgedNeoplasm StagingRadiation DosageTime Factors
Funding
- Sanofi
Citations
1,860
FWCI
61.09
field-weighted impact
References
41
Percentile
100%
vs. same field & year
Citations per year
Cited by
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Annals of Oncology · 2017 · 2,299 citations
References
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Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): An update on 93 randomised trials and 17,346 patients
Radiotherapy and Oncology · 2009 · 3,022 citations
Quantifying heterogeneity in a meta‐analysis
Statistics in Medicine · 2002 · 36,106 citations
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