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Reactivity of a monoclonal antibody with human ovarian carcinoma.

Journal of Clinical Investigation · 1981 · Vol. 68(5) · pp. 1331–1337

Robert C. Bast✉Maryellen Feeney(Harvard University Press)Herbert Lazarus(Harvard University Press)Lee M. Nadler(Harvard University)Robert B. Colvin(Brigham and Women's Hospital)Robert C. Knapp(Dana-Farber Brigham Cancer Center)

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Abstract

A murine monoclonal antibody (OC125) has been developed that reacts with each of six epithelial ovarian carcinoma cell lines and with cryopreserved tumor tissue from 12 of 20 ovarian cancer patients. By contrast, the antibody does not bind to a variety of nonmalignant tissues, including adult and fetal ovary. OC125 reacts with only 1 of 14 cell lines derived from nonovarian neoplasms and has failed to react with cryostat sections from 12 nonovarian carcinomas.

Monoclonal and Polyclonal Antibodies Research Glycosylation and Glycoproteins Research Galectins and Cancer BiologyMonoclonal antibodyOvaryOvarian carcinomaPathologyAntibodyOvarian cancerCarcinomaCancer researchMonoclonalBiology