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Enrichment Map: A Network-Based Method for Gene-Set Enrichment Visualization and Interpretation

PLoS ONE · 2010 · Vol. 5(11) · pp. e13984–e13984

Daniele Merico✉(University of Toronto)Ruth Isserlin(University of Toronto)Oliver Stueker(University of Toronto)Andrew Emili(University of Toronto)Gary D. Bader(University of Toronto)

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Abstract

Enrichment Map is a significant advance in the interpretation of enrichment analysis. Any research project that generates a list of genes can take advantage of this visualization framework. Enrichment Map is implemented as a freely available and user friendly plug-in for the Cytoscape network visualization software (http://baderlab.org/Software/EnrichmentMap/).

Bioinformatics and Genomic Networks Gene expression and cancer classification Gene Regulatory Network AnalysisVisualizationComputer scienceRedundancy (engineering)Gene regulatory networkSet (abstract data type)Data miningSoftwareGene expression profilingGeneComputational biology

MeSH terms

AlgorithmsBreast NeoplasmsColonic NeoplasmsEstrogensFemaleHumansSoftwareReproducibility of ResultsGene Expression Regulation, NeoplasticCluster AnalysisComputational BiologyInternetGene Expression ProfilingGene Regulatory Networks

Funding

Heart and Stroke Foundation of Canada
Genome Canada
Ontario Genomics
Ontario Genomics Institute
Hospital for Sick Children
National Institutes of Health
National Human Genome Research Institute

Citations

2,406

FWCI

17.04

field-weighted impact

References

58

Percentile

100%

vs. same field & year

Citations per year

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References

Global functional profiling of gene expression☆☆This work was funded in part by a Sun Microsystems grant awarded to S.D., NIH Grant HD36512 to S.A.K., a Wayne State University SOM Dean’s Post-Doctoral Fellowship, and an NICHD Contraception and Infertility Loan to G.C.O. Support from the WSU MCBI mode is gratefully appreciated.

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