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Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins

Nature Immunology · 2003 · Vol. 5(1) · pp. 74–80

Marika J. Karkkainen✉Paula Haiko(University of Helsinki)Kirsi SainioJuha Partanen(University of Helsinki)Jussi Taipale(Ludwig Cancer Research)Tatiana V. Petrova(Ludwig Cancer Research)Michael Jeltsch(Helsinki University Hospital)David G. Jackson(John Radcliffe Hospital)Marja Talikka(University of Helsinki)Heikki Rauvala(University of Helsinki)Christer Betsholtz(University of Gothenburg)Kari Alitalo(Helsinki University Hospital)

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Lymphatic System and Diseases Sympathectomy and Hyperhidrosis Treatments Hippo pathway signaling and YAP/TAZLymphatic systemVascular endothelial growth factor CLymphangiogenesisLymphatic EndotheliumBiologyLymphatic vesselLymph node stromal cellVascular endothelial growth factor BVascular endothelial growth factorLymphedema

MeSH terms

AnimalsFemaleEmbryonic and Fetal DevelopmentImmunohistochemistryLymphedemaMaleMice, Inbred ICRMicroscopy, FluorescenceMice, KnockoutReceptors, Vascular Endothelial Growth FactorVascular Endothelial Growth Factor Receptor-3Vascular Endothelial Growth Factor CLymphangiogenesisLymphatic VesselsMice

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Role of the Vascular Endothelial Growth Factor Pathway in Tumor Growth and Angiogenesis