reviewTop 1% cited

Playing with bone and fat

Journal of Cellular Biochemistry · 2006 · Vol. 98(2) · pp. 251–266

Jeffrey M. Gimble✉(Louisiana State University System)Sanjin Zvonic(Pennington Biomedical Research Center)Z. Elizabeth Floyd(Pennington Biomedical Research Center)Moustapha Kassem(Odense University Hospital)Mark Nuttall(Johnson & Johnson (United States))

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Abstract

The relationship between bone and fat formation within the bone marrow microenvironment is complex and remains an area of active investigation. Classical in vitro and in vivo studies strongly support an inverse relationship between the commitment of bone marrow-derived mesenchymal stem cells or stromal cells to the adipocyte and osteoblast lineage pathways. In this review, we focus on the recent literature exploring the mechanisms underlying these differentiation events and discuss their implications relevant to osteoporosis and regenerative medicine.

Mesenchymal stem cell research Fibroblast Growth Factor Research Bone Metabolism and DiseasesMesenchymal stem cellBone marrowStromal cellOsteoblastLineage (genetic)OsteoporosisBone formationIn vivoCell biologyIn vitro

MeSH terms

Adipose TissueAnimalsBone and BonesBone Diseases, MetabolicCell DifferentiationChildCholesterolHematopoiesisHumansObesityOsteogenesisOsteoporosisProtease InhibitorsReceptors, SteroidSignal Transduction

Citations

493

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16.58

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153

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100%

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