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Potential Role of Microglia in Retinal Blood Vessel Formation

Investigative Ophthalmology & Visual Science · 2006 · Vol. 47(8) · pp. 3595–3595

Daniella Checchin✉(McGill University)Florian Sennlaub(Inserm)Etienne LevavasseurMartin Leduc(Centre Hospitalier Universitaire Sainte-Justine)Sylvain Chemtob(McGill University)

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Abstract

These observations suggest that proper retinal blood vessel formation requires an adequate resident microglial population because diminished microglia are associated with decreased vascularity in models of ischemic retinopathy and retinal vascular development. In light of these findings, the traditional definition of microglia as merely immunocompetent cells should be reconsidered to encompass this new function related to blood vessel formation.

Neuroinflammation and Neurodegeneration Mechanisms Retinal Diseases and Treatments Atherosclerosis and Cardiovascular DiseasesMicrogliaRetinalRetinopathy of prematurityRetinaCX3CR1PathologyBiologyImmunologyMedicineNeuroscience

MeSH terms

CX3C Chemokine Receptor 1AnimalsClodronic AcidHumansHypercapniaInfant, NewbornLiposomesMacrophagesMice, Inbred C57BLMorphogenesisOxygenRetinaRetinal VesselsRetinopathy of PrematurityRats, Sprague-Dawley

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376

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Microglia: biology and pathology