article Open AccessTop 1% cited
Novel p19 Protein Engages IL-12p40 to Form a Cytokine, IL-23, with Biological Activities Similar as Well as Distinct from IL-12
Immunity · 2000 · Vol. 13(5) · pp. 715–725
Birgit OppmannRobin LesleyBianca BlomJackie C. TimansYuming XuBrisdell HunteFélix V. VegaNancy YuJing WangKomal SinghFrancesca ZoninElena VaisbergTatyana ChurakovaMan-ru LiuDaniel M. GormanJanet WagnerSandra ZurawskiYong‐Jun LiuJohn S. AbramsKevin W. MooreD RennickRené de Waal MalefytCharles HannumJ. Fernando BazánRobert A. Kastelein✉
Cytokine Signaling Pathways and InteractionsT-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesBiologyCytokineCell biologyProtein subunitSecretionInterleukin 12Interleukin 23PopulationSTAT4Immunology
MeSH terms
Amino Acid SequenceAnimalsHumansInterleukinsMolecular Sequence DataCD4-Positive T-LymphocytesCytokinesDatabases, FactualSequence AlignmentSequence AnalysisInterleukin-12MiceInterleukin-23Interleukin-23 Subunit p19
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Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells.
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