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A systematic review and meta-analysis of familial colorectal cancer risk
The American Journal of Gastroenterology · 2001 · Vol. 96(10) · pp. 2992–3003
Louise Johns✉(Institute of Cancer Research)Richard S. Houlston(Institute of Cancer Research)
Abstract
Individuals with a family history of CRC and CRA have a significantly elevated risk of developing CRC compared with those without such a history. Risks are greatest for relatives of patients diagnosed young, those with two or more affected relatives, and relatives of patients with colonic cancers.
Genetic factors in colorectal cancerColorectal Cancer Screening and DetectionMultiple and Secondary Primary CancersMedicineColorectal cancerFamily historyRelative riskInternal medicineFirst-degree relativesMeta-analysisSiblingCancerDemography
MeSH terms
AdenomaHumansRisk FactorsColorectal NeoplasmsAge of Onset
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References
Estimates of the worldwide incidence of eighteen major cancers in 1985
International Journal of Cancer · 1993 · 1,655 citations
Bias in meta-analysis detected by a simple, graphical test
BMJ · 1997 · 55,187 citations
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