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Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

Nature Neuroscience · 2002 · Vol. 5(5) · pp. 405–414
Giles E. HardinghamYuko FukunagaHilmar Bading
Neuroscience and Neuropharmacology ResearchNeuroscience and Neural EngineeringPhotoreceptor and optogenetics researchCREBNMDA receptorGlutamate receptorNeuroscienceLong-term depressionNeurotrophic factorsReceptorBrain-derived neurotrophic factorNeurotrophinBiology

MeSH terms

CalciumCell SurvivalCells, CulturedEnzyme InhibitorsGene Expression RegulationIntracellular MembranesMembrane PotentialsMitochondriaNeuronsPiperidinesRNA, MessengerSynapsesSignal TransductionCell HypoxiaReceptors, N-Methyl-D-Aspartate
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