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Platelet‐Rich Plasma: Growth Factors and Pro‐ and Anti‐Inflammatory Properties

Journal of Periodontology · 2007 · Vol. 78(4) · pp. 661–669

Hesham El‐Sharkawy(Boston University)Alpdoğan Kantarcı(Boston University)Jennifer Deady(Boston University)Hatice Hastürk(Boston University)Hongsheng Liu(Boston University)Mohammad Alshahat(Mansoura University)Thomas E. Van Dyke✉(Boston University)

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Abstract

PRP is a rich source of growth factors and promoted significant changes in monocyte-mediated proinflammatory cytokine/chemokine release. LXA(4) was increased in PRP, suggesting that PRP may suppress cytokine release, limit inflammation, and, thereby, promote tissue regeneration.

Periodontal Regeneration and Treatments Dental Trauma and Treatments Oral and Maxillofacial PathologyMonocyteChemokineGrowth factorCytokineProinflammatory cytokineChemotaxisPlatelet-rich plasmaPlatelet-derived growth factorCCL2Chemistry

MeSH terms

AdultChemotaxis, LeukocyteFemaleHumansMaleMiddle AgedMonocytesPlatelet CountCytokinesChemokine CCL5Intercellular Signaling Peptides and ProteinsLipoxinsPlatelet-Rich Plasma