articleTop 10% cited

MEK/ERK signaling pathway regulates the expression of Bcl-2, Bcl-XL, and Mcl-1 and promotes survival of human pancreatic cancer cells

Journal of Cellular Biochemistry · 2000 · Vol. 79(3) · pp. 355–369

Marie-Jos�e Boucher(Université de Sherbrooke)Jean Morisset(Université de Sherbrooke)Pierre H. Vachon(Université de Sherbrooke)John C. Reed(Université de Sherbrooke)Jean Lain�(Université de Sherbrooke)Nathalie Rivard✉(Université de Sherbrooke)

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Abstract

Our data suggest that activation of the ERK pathway functions to protect pancreatic tumor cells from apoptosis as well as to regulate their progression in the cell cycle.

Cell death mechanisms and regulation Cancer Mechanisms and Therapy Melanoma and MAPK PathwaysMAPK/ERK pathwayBcl-xLPancreatic cancerCancer researchApoptosisSignal transductionCell biologyCancerBiologyProgrammed cell death

MeSH terms

CarcinomaCell CycleCell SurvivalCysteine EndopeptidasesEnzyme ActivationEnzyme InhibitorsFlavonoidsHumansImidazolesMultienzyme ComplexesNeoplasm ProteinsPancreatic NeoplasmsPoly(ADP-ribose) PolymerasesProstaglandin-Endoperoxide SynthasesPyridines

Citations

411

FWCI

7.08

field-weighted impact

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98%

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References

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation