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In Vivo Depletion of CD11c+ Dendritic Cells Abrogates Priming of CD8+ T Cells by Exogenous Cell-Associated Antigens

Immunity · 2002 · Vol. 17(2) · pp. 211–220

Steffen Jung✉(New York University)Derya Unutmaz(New York University)Phillip Wong(Memorial Sloan Kettering Cancer Center)Gen‐ichiro Sano(New York University)Kenia de los Santos(New York University)Tim Sparwasser(Howard Hughes Medical Institute)Shengji Wu(New York University)Sri Vuthoori(New York University)Kyung Ae Ko(New York University)Fidel Zavala(New York University)Eric G. Pamer(Memorial Sloan Kettering Cancer Center)Dan R. Littman(Howard Hughes Medical Institute)Richard A. Lang(New York University)

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Immunotherapy and Immune Responses T-cell and B-cell Immunology Immune Cell Function and InteractionBiologyCross-presentationCytotoxic T cellCTL*Priming (agriculture)AntigenAntigen presentationDendritic cellMHC class IAntigen-presenting cell

MeSH terms

AnimalsDendritic CellsDiphtheria ToxinListeria monocytogenesLiverMice, Inbred BALB CMice, Inbred C57BLMice, TransgenicPlasmodium yoeliiReceptors, Cell SurfaceRecombinant Fusion ProteinsT-Lymphocytes, CytotoxicIntegrin alphaXbeta2CD8-Positive T-LymphocytesModels, Animal

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The Dendritic Cell Lineage: Ontogeny and Function of Dendritic Cells and Their Subsets in the Steady State and the Inflamed Setting