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Seven-Year Efficacy and Safety of Treatment with Tenofovir Disoproxil Fumarate for Chronic Hepatitis B Virus Infection
Digestive Diseases and Sciences · 2014 · Vol. 60(5) · pp. 1457–1464
Marı́a Buti✉Naoky Tsai(Queen's Medical Center)Joerg Petersen(Asklepios Klinik St. Georg)Robert Flisiak(University of Białystok)Selım Gürel(Bursa Uludağ Üni̇versi̇tesi̇)Zahary Krastev(University Hospital St. Ivan Rilski)Raul Aguilar Schall(Gilead Sciences (United States))John F. Flaherty(Gilead Sciences (United States))Eduardo B. Martins(Gilead Sciences (United States))Prista Charuworn(Gilead Sciences (United States))Kathryn M. Kitrinos(Gilead Sciences (United States))G. Mani Subramanian(Gilead Sciences (United States))Edward Gane(Auckland City Hospital)Patrick Marcellin(Hôpital Beau-Séjour)
Abstract
Long-term TDF treatment was associated with sustained virologic, biochemical, and serologic responses, without resistance. TDF treatment was well tolerated, with a low incidence of renal and bone events. These data confirm the safety and efficacy of long-term TDF for CHB.
Hepatitis B Virus StudiesHepatitis C virus researchLiver Disease Diagnosis and TreatmentMedicineAdefovirInternal medicineGastroenterologyHBeAgHBsAgHepatologyCirrhosisAdverse effectHepatitis B virus
MeSH terms
AdenineAntiviral AgentsDNA, ViralDrug Administration ScheduleHepatitis B e AntigensHepatitis B virusHumansPhosphorous AcidsTime FactorsBiomarkersTreatment OutcomeViral LoadHepatitis B, ChronicDrug Resistance, Viral
Funding
- Gilead Sciences
Citations
297
FWCI
19.52
field-weighted impact
References
23
Percentile
100%
vs. same field & year
Citations per year
Cited by
AASLD guidelines for treatment of chronic hepatitis B
Hepatology · 2015 · 1,996 citations
EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection
Journal of Hepatology · 2017 · 5,359 citations
References
Predicting Cirrhosis Risk Based on the Level of Circulating Hepatitis B Viral Load
Gastroenterology · 2006 · 1,533 citations
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