article Open AccessTop 10% cited
Cytokines play an aetiopathogenetic role in fibromyalgia: a hypothesis and pilot study
Lara D. Veeken · 2001 · Vol. 40(7) · pp. 743–749
Daniel J. Wallace✉(Cedars-Sinai Medical Center)Mariana Linker‐Israeli(Cedars-Sinai Medical Center)David S. Hallegua(Cedars-Sinai Medical Center)Stuart L. Silverman(Cedars-Sinai Medical Center)David Silver(Cedars-Sinai Medical Center)Michael H. Weisman(Cedars-Sinai Medical Center)
Abstract
In patients with FM we found increases over time in serum levels and/or PBMC-stimulated activity of soluble factors whose release is stimulated by substance P. Because IL-8 promotes sympathetic pain and IL-6 induces hyperalgesia, fatigue and depression, it is hypothesized that they may play a role in modulating FM symptoms.
Fibromyalgia and Chronic Fatigue Syndrome ResearchMusculoskeletal pain and rehabilitationPain Mechanisms and TreatmentsMedicineCytokinePeripheral blood mononuclear cellFibromyalgiaInternal medicineEndocrinologyTumor necrosis factor alphaImmunologyInterleukinInterleukin 6
MeSH terms
Enzyme-Linked Immunosorbent AssayFemaleFibromyalgiaHumansLipopolysaccharidesLymphocyte ActivationMaleMiddle AgedMonocytesPhytohemagglutininsPilot ProjectsSurveys and QuestionnairesTetradecanoylphorbol AcetateCytokines
Funding
- American Fibromyalgia Syndrome Association
- National Institutes of Health
Citations
330
FWCI
5.01
field-weighted impact
References
34
Percentile
96%
vs. same field & year
Citations per year
References
The american college of rheumatology 1990 criteria for the classification of fibromyalgia
Arthritis & Rheumatism · 1990 · 9,551 citations
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