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Principles of encapsulating hydrophobic drugs in PLA/PLGA microparticles

International Journal of Pharmaceutics · 2008 · Vol. 364(2) · pp. 298–327

Christian Wischke(University of Michigan–Ann Arbor)Steven P. Schwendeman✉(University of Michigan–Ann Arbor)

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Advanced Drug Delivery Systems Drug Solubulity and Delivery Systems Inhalation and Respiratory Drug DeliveryMicroparticlePLGABiopharmaceuticalPolylactic acidDrug deliveryBiocompatible materialDrugBioavailabilityNanotechnologyChemistry

MeSH terms

Polylactic Acid-Polyglycolic Acid CopolymerChemistry, PharmaceuticalDelayed-Action PreparationsDrug CarriersPharmaceutical PreparationsMicrospheresPolyestersPolyglycolic AcidPolymersSolventsDrug Delivery SystemsLactic AcidHydrophobic and Hydrophilic Interactions

Citations

776

FWCI

22.31

field-weighted impact

References

373

Percentile

100%

vs. same field & year

Citations per year

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References

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Establishment of sink conditions in dissolution rate determinations. Theoretical considerations and application to nondisintegrating dosage forms

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A new technique to efficiently entrap leuprolide acetate into microcapsules of polylactic acid or copoly(lactic/glycolic) acid.

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Biodegradable microspheres for protein delivery

Journal of Controlled Release · 2003 · 800 citations

Transporters and drug therapy: Implications for drug disposition and disease

Clinical Pharmacology & Therapeutics · 2005 · 496 citations

Why degradable polymers undergo surface erosion or bulk erosion

Biomaterials · 2002 · 1,097 citations

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