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Selective cytotoxicity of betulinic acid on tumor cell lines, but not on normal cells

Cancer Letters · 2002 · Vol. 175(1) · pp. 17–25
Valentina ZucoRosanna SupinoSabina Carla RighettiLoredana ClerisEdoardo MarchesiCarlo Gambacorti‐PasseriniFranca Formelli
Natural product bioactivities and synthesisPlant biochemistry and biosynthesisBiological Activity of Diterpenoids and BiflavonoidsBetulinic acidCell cultureCytotoxicityDoxorubicinCytotoxic T cellBiologyMelanomaCancer researchclone (Java method)In vivo

MeSH terms

Betulinic AcidAntineoplastic AgentsCell CycleCell DivisionCell LineCell SurvivalDose-Response Relationship, DrugExonsHumansKineticsOleanolic AcidReference ValuesTumor Cells, CulturedGenes, p53Tumor Suppressor Protein p53
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