reviewTop 10% cited
Nrf2 as a novel molecular target for chemoprevention
Cancer Letters · 2004 · Vol. 224(2) · pp. 171–184
Jeong‐Sang Lee(Seoul National University)Young‐Joon Surh✉(Seoul National University)
Genomics, phytochemicals, and oxidative stressGlutathione Transferases and PolymorphismsFree Radicals and AntioxidantsBiochemistryKEAP1KinaseGlutathioneTranscription factorBiologySulforaphaneDNA damageUbiquitin ligaseChemistry
MeSH terms
AntioxidantsCarcinogensDNA DamageDNA-Binding ProteinsEnzyme InductionHumansProtein KinasesSignal TransductionTrans-ActivatorsLeucine ZippersChemopreventionNF-E2-Related Factor 2
Funding
- Fonds National de la Recherche Luxembourg
Citations
515
FWCI
8.29
field-weighted impact
References
139
Percentile
99%
vs. same field & year
Citations per year
Cited by
Antioxidants and human diseases
Clinica Chimica Acta · 2014 · 511 citations
Regulation of inflammation and redox signaling by dietary polyphenols
Biochemical Pharmacology · 2006 · 975 citations
Nrf2:INrf2 (Keap1) signaling in oxidative stress
Free Radical Biology and Medicine · 2009 · 1,632 citations
Molecular basis for chemoprevention by sulforaphane: a comprehensive review
Cellular and Molecular Life Sciences · 2007 · 694 citations
Modulation of Nrf2-mediated antioxidant and detoxifying enzyme induction by the green tea polyphenol EGCG
Food and Chemical Toxicology · 2007 · 471 citations
Multitargeted cancer prevention by quercetin
Cancer Letters · 2008 · 713 citations
Cancer chemopreventive and therapeutic potential of resveratrol: Mechanistic perspectives
Cancer Letters · 2008 · 466 citations
References
An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements
Biochemical and Biophysical Research Communications · 1997 · 3,915 citations
Cancer chemoprevention with dietary phytochemicals
Nature reviews. Cancer · 2003 · 2,928 citations
Cytochromes P450 and metabolism of xenobiotics
Cellular and Molecular Life Sciences · 2001 · 884 citations
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
Genes & Development · 1999 · 3,543 citations
Chemoprevention of cancer
Carcinogenesis · 2000 · 442 citations
Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element
Biochemical Journal · 2003 · 1,018 citations
Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress
Molecular and Cellular Biology · 2003 · 1,425 citations
Related articles
The Keap1-BTB Protein Is an Adaptor That Bridges Nrf2 to a Cul3-Based E3 Ligase: Oxidative Stress Sensing by a Cul3-Keap1 Ligase
Molecular and Cellular Biology · 2004 · 967 citations
Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2
Molecular and Cellular Biology · 2004 · 2,165 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.