article Open AccessTop 10% cited
Synthetic furanones inhibit quorum-sensing and enhance bacterial clearance in Pseudomonas aeruginosa lung infection in mice
Journal of Antimicrobial Chemotherapy · 2004 · Vol. 53(6) · pp. 1054–1061
Hong Wu✉(Rigshospitalet)
Abstract
Synthetic furanone compounds inhibited bacterial quorum-sensing in P. aeruginosa and exhibited favourable therapeutic effects on P. aeruginosa lung infection.
Bacterial biofilms and quorum sensingAntimicrobial Peptides and ActivitiesNosocomial Infections in ICUQuorum sensingPseudomonas aeruginosaMicrobiologyVirulenceBacteriaHomoserineAntibioticsBiofilmEscherichia coliBiology
MeSH terms
AlginatesAnimalsAnti-Infective AgentsFuransLungLung DiseasesPseudomonas aeruginosaPseudomonas InfectionsSurvival AnalysisMiceEukaryota
Funding
- Sundhed og Sygdom, Det Frie Forskningsråd
- Teknologi og Produktion, Det Frie Forskningsråd
- Rigshospitalet
- Medical Research Council
Citations
442
FWCI
7.09
field-weighted impact
References
37
Percentile
98%
vs. same field & year
Citations per year
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References
Applied and Environmental Microbiology
Applied and Environmental Microbiology · 2018 · 5,346 citations
Halogenated furanones inhibit quorum sensing through accelerated LuxR turnover
Microbiology · 2002 · 591 citations
Roles of Pseudomonas aeruginosa las and rhl quorum-sensing systems in control of elastase and rhamnolipid biosynthesis genes
Journal of Bacteriology · 1997 · 1,028 citations
Evidence that halogenated furanones from Delisea pulchra inhibit acylated homoserine lactone (AHL)-mediated gene expression by displacing the AHL signal from its receptor protein
Microbiology · 1999 · 609 citations
Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound
Microbiology · 2002 · 1,033 citations
Bacterial Quorum Sensing in Pathogenic Relationships
Infection and Immunity · 2000 · 1,107 citations
Bacterial Biofilms: A Common Cause of Persistent Infections
Science · 1999 · 11,895 citations
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