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CS1-specific chimeric antigen receptor (CAR)-engineered natural killer cells enhance in vitro and in vivo antitumor activity against human multiple myeloma

Leukemia · 2013 · Vol. 28(4) · pp. 917–927

Jianjun Chu✉(The Ohio State University)Youcai Deng(The Ohio State University)D.M. Benson(The Ohio State University)Shun He(The Ohio State University)Tiffany Hughes(The Ohio State University)Jian Zhang(The Ohio State University)Yong Peng(The Ohio State University)Hongyi Mao(The Ohio State University)Ling Yi(The Ohio State University)Kalpana Ghoshal(The Ohio State University)Xiaoming He(The Ohio State University)Steven M. Devine(The Ohio State University)Xiaoliu Zhang(University of Houston)Michael A. Caligiuri(The Ohio State University)Craig C. Hofmeister(The Ohio State University)Jianhua Yu(The Ohio State University)

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Immune Cell Function and Interaction CAR-T cell therapy research T-cell and B-cell ImmunologyChimeric antigen receptorAdoptive cell transferNK-92ImmunologyCancer researchInterleukin 12AntigenInterleukin 21BiologyImmune system

MeSH terms

Signaling Lymphocytic Activation Molecule FamilyAnimalsCells, CulturedCytotoxicity, ImmunologicGenetic EngineeringHumansInterferon-gammaKiller Cells, NaturalMultiple MyelomaPhenotypeReceptors, AntigenReceptors, ImmunologicLentivirusMice, Inbred NODXenograft Model Antitumor Assays

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13.51

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The Molecular Mechanism of Natural Killer Cells Function and Its Importance in Cancer Immunotherapy