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Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps

Cell Death and Differentiation · 2009 · Vol. 16(11) · pp. 1438–1444
Shída YousefiCristina C. MihalacheEsther KozlowskiInès SchmidHans‐Uwe Simon
Neutrophil, Myeloperoxidase and Oxidative MechanismsImmune cells in cancerImmune Response and InflammationNeutrophil extracellular trapsCell biologyExtracellularProgrammed cell deathBiologyMitochondrial DNAGranulocyteTLR4ApoptosisReactive oxygen species

MeSH terms

DNA, MitochondrialHumansNeutrophilsComplement C5aGranulocyte-Macrophage Colony-Stimulating FactorApoptosisReactive Oxygen SpeciesNeutrophil ActivationToll-Like Receptor 4

Funding

  • National Science Foundation
  • Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Citations
966
FWCI
7.73
field-weighted impact
References
17
Percentile
98%
vs. same field & year
Citations per year
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Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality
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References
Neutrophils and immunity: challenges and opportunities
Nature reviews. Immunology · 2006 · 2,901 citations
Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis
Nature Cell Biology · 2006 · 1,272 citations
Neutrophil Extracellular Traps Kill Bacteria
Science · 2004 · 9,872 citations
Novel cell death program leads to neutrophil extracellular traps
The Journal of Cell Biology · 2007 · 3,097 citations
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