reviewTop 1% cited

PI3K and cancer: lessons, challenges and opportunities

Nature Reviews Drug Discovery · 2014 · Vol. 13(2) · pp. 140–156

David A. Fruman✉(University of California, Irvine)Christian Rommel✉(Amgen (United States))

Chronic Lymphocytic Leukemia Research PI3K/AKT/mTOR signaling in cancer Immunodeficiency and Autoimmune DisordersPI3K/AKT/mTOR pathwayProtein kinase BCancerDiscovery and development of mTOR inhibitorsCancer researchKinaseComputational biologyBiologyMedicineSignal transduction

MeSH terms

Phosphoinositide-3 Kinase InhibitorsAnimalsAntineoplastic AgentsClinical Trials as TopicEnzyme InhibitorsHumansNeoplasmsSignal TransductionReceptor Cross-TalkProto-Oncogene Proteins c-aktDrug DiscoveryTOR Serine-Threonine Kinases

Citations

1,716

FWCI

102.41

field-weighted impact

References

232

Percentile

100%

vs. same field & year

Citations per year

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References

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Cancer Cell · 2002 · 1,634 citations

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Nature reviews. Cancer · 2009 · 2,438 citations

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Biochemical Journal · 2008 · 1,234 citations

Oncology Meets Immunology: The Cancer-Immunity Cycle

Immunity · 2013 · 6,760 citations

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

Nature Reviews Genetics · 2006 · 3,288 citations

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

Cancer Cell · 2006 · 1,253 citations

Hallmarks of Cancer: The Next Generation

Cell · 2011 · 65,668 citations

mTOR Signaling in Growth Control and Disease

Cell · 2012 · 8,373 citations

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