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Chloroquine potentiates the anti-cancer effect of 5-fluorouracil on colon cancer cells

BMC Cancer · 2010 · Vol. 10(1) · pp. 370–370

Kazuhito Sasaki✉(The University of Tokyo)Nelson H. Tsuno(The University of Tokyo)Eiji Sunami(The University of Tokyo)Giichiro Tsurita(The University of Tokyo)Kazushige Kawai(The University of Tokyo)Yurai Okaji(The University of Tokyo)Takeshi Nishikawa(The University of Tokyo)Yasutaka Shuno(The University of Tokyo)Kumiko Hongo(The University of Tokyo)Masaya Hiyoshi(The University of Tokyo)Manabu Kaneko(The University of Tokyo)Joji Kitayama(The University of Tokyo)Koki Takahashi(The University of Tokyo)Hirokazu Nagawa(The University of Tokyo)

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Abstract

Our findings suggest that the combination therapy with CQ should be a novel therapeutic modality to improve efficacy of 5-FU-based chemotherapy, possibly by inhibiting autophagy-dependent resistance to chemotherapy.

Autophagy in Disease and Therapy Cancer-related Molecular Pathways Histone Deacetylase Inhibitors ResearchApoptosisCell cycleFlow cytometryCancer cellCancer researchColorectal cancerCell growthChemosensitizerPharmacologyCancer

MeSH terms

AntimalarialsAntimetabolites, AntineoplasticAntineoplastic Combined Chemotherapy ProtocolsAutophagyCell CycleChloroquineColonic NeoplasmsColony-Forming Units AssayDrug SynergismFlow CytometryFluorouracilHumansImmunoenzyme TechniquesBlotting, WesternApoptosis