articleTop 1% cited

Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

Nature Medicine · 2002 · Vol. 8(11) · pp. 1288–1295

Toshimasa Yamauchi✉(The University of Tokyo)Junji Kamon(The University of Tokyo)Yasuhiko Minokoshi(Beth Israel Deaconess Medical Center)Yusuke Ito(The University of Tokyo)Hironori Waki(The University of Tokyo)Shoko Uchida(The University of Tokyo)Satoshi Yamashita(The University of Tokyo)Mitsuhiko Noda(Japan Science and Technology Agency)Shunbun Kita(The University of Tokyo)Kohjiro Ueki(The University of Tokyo)Kazuhiro Eto(The University of Tokyo)Y Akanuma(Japan Science and Technology Agency)Philippe Froguel(Institut Pasteur de Lille)Fabienne Foufelle(Inserm)Pascal Ferré(Inserm)David Carling(Hammersmith Hospital)Satoshi Kimura(The University of Tokyo)R Nagai(The University of Tokyo)Barbara B. Kahn(Harvard University)Takashi Kadowaki(Japan Science and Technology Agency)

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Metabolism, Diabetes, and Cancer Adipokines, Inflammation, and Metabolic Diseases Adipose Tissue and MetabolismAMPKAMP-activated protein kinaseProtein kinase ABeta oxidationGlucose homeostasisChemistryGlucose uptakeGluconeogenesisEndocrinologyPhosphorylation

MeSH terms

Acetyl-CoA CarboxylaseAnimalsEnzyme ActivationFatty AcidsGlucoseMaleMice, Inbred C57BLOxidation-ReductionPhosphorylationProteinsCyclic AMP-Dependent Protein KinasesMuscle, SkeletalHepatocytesIntercellular Signaling Peptides and ProteinsMice

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Minireview: The AMP-Activated Protein Kinase Cascade: The Key Sensor of Cellular Energy Status