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Shedding of syncytiotrophoblast microvilli into the maternal circulation in pre‐eclamptic pregnancies

BJOG An International Journal of Obstetrics & Gynaecology · 1998 · Vol. 105(6) · pp. 632–640

Marian Knight✉(John Radcliffe Hospital)Christopher Redman(John Radcliffe Hospital)Elizabeth A. Linton(John Radcliffe Hospital)Ian L. Sargent(John Radcliffe Hospital)

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Abstract

STBM are shed into the maternal circulation (microvillous deportation) and are present in significantly increased amounts in pre-eclamptic women. They may contribute to the endothelial dysfunction underlying the maternal syndrome of pre-eclampsia.

Pregnancy and preeclampsia studies Maternal and fetal healthcare Reproductive System and PregnancySyncytiotrophoblastMedicineEclampsiaPlacentaPreeclampsiaInternal medicinePlacental CirculationEndocrinologyEndothelial dysfunctionPregnancy