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Tumor Angiogenesis: A New Significant and Independent Prognostic Indicator in Early-Stage Breast Carcinoma

JNCI Journal of the National Cancer Institute · 1992 · Vol. 84(24) · pp. 1875–1887

Noel Weidner✉J Folkman(Harvard University)F. Pozza(Ospedale San Bortolo)Pierantonio Bevilacqua(Ospedale San Bortolo)Elizabeth N. AllredDan H. Moore(Lawrence Livermore National Laboratory)S Meli(Ospedale San Bortolo)Giampietro Gasparini(Ospedale San Bortolo)

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Abstract

Such an indicator would be useful in selection of those node-negative patients with breast carcinoma who are at high risk for having occult metastasis at presentation. These patients could then be given systemic adjuvant therapy.

Angiogenesis and VEGF in Cancer Breast Cancer Treatment Studies Lymphatic System and DiseasesMedicineBreast carcinomaBreast cancerOncologyInternal medicineMicrovesselUnivariate analysisAngiogenesisCarcinomaStage (stratigraphy)

MeSH terms

AdultAgedAged, 80 and overBreast NeoplasmsFemaleHumansLymphatic MetastasisMicrocirculationMiddle AgedNeovascularization, PathologicPrognosisSurvival Rate

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Cited by

Quantification of angiogenesis in solid human tumours: an international consensus on the methodology and criteria of evaluation